| Sunday, January 1st, 2006 |
| Fired general manager Y. Wilder. |
| Drafted SP D. Kennahan in the 2006 inaugural draft (Round 1, Pick 1, 1st overall Pick). |
| Drafted LF G. Foreman in the 2006 inaugural draft (Round 2, Pick 1, 3rd overall Pick). |
| Drafted C A. Domínguez in the 2006 inaugural draft (Round 3, Pick 1, 5th overall Pick). |
| Drafted SP R. Coker in the 2006 inaugural draft (Round 4, Pick 1, 7th overall Pick). |
| Drafted CF K. Bradley in the 2006 inaugural draft (Round 5, Pick 1, 9th overall Pick). |
| Drafted RF B. O'Danaher in the 2006 inaugural draft (Round 6, Pick 1, 11th overall Pick). |
| Drafted SP J. Pocklington in the 2006 inaugural draft (Round 7, Pick 1, 13th overall Pick). |
| Drafted CL P. Parkman in the 2006 inaugural draft (Round 8, Pick 1, 15th overall Pick). |
| Drafted 1B T. Shrimpton in the 2006 inaugural draft (Round 9, Pick 1, 17th overall Pick). |
| Drafted 2B E. Valadón in the 2006 inaugural draft (Round 10, Pick 1, 19th overall Pick). |
| Drafted 3B B. Bagoim in the 2006 inaugural draft (Round 11, Pick 1, 21st overall Pick). |
| Drafted SP C. O'Muleeny in the 2006 inaugural draft (Round 12, Pick 1, 23rd overall Pick). |
| Drafted SP Z. Newson in the 2006 inaugural draft (Round 13, Pick 1, 25th overall Pick). |
| Drafted MR G. Scott in the 2006 inaugural draft (Round 14, Pick 1, 27th overall Pick). |
| Drafted C K. Smith in the 2006 inaugural draft (Round 15, Pick 1, 29th overall Pick). |
| Drafted SS M. Knapp in the 2006 inaugural draft (Round 16, Pick 1, 31st overall Pick). |
| Drafted MR L. Batista in the 2006 inaugural draft (Round 17, Pick 1, 33rd overall Pick). |
| Drafted MR C. Whipple in the 2006 inaugural draft (Round 18, Pick 1, 35th overall Pick). |
| Drafted MR M. Scott in the 2006 inaugural draft (Round 19, Pick 1, 37th overall Pick). |
| Drafted MR J. Castellar in the 2006 inaugural draft (Round 20, Pick 1, 39th overall Pick). |
| Drafted LF E. McShannachan in the 2006 inaugural draft (Round 21, Pick 1, 41st overall Pick). |
| Drafted CF M. Roach in the 2006 inaugural draft (Round 22, Pick 1, 43rd overall Pick). |
| Drafted 1B A. Chaney in the 2006 inaugural draft (Round 23, Pick 1, 45th overall Pick). |
| Drafted 3B T. Tarter in the 2006 inaugural draft (Round 24, Pick 1, 47th overall Pick). |
| Drafted SP C. Young in the 2006 inaugural draft (Round 25, Pick 1, 49th overall Pick). |
| Drafted 1B Á. Cantorán in the 2006 inaugural draft (Round 26, Pick 1, 51st overall Pick). |
| Drafted SP A. Salinas in the 2006 inaugural draft (Round 27, Pick 1, 53rd overall Pick). |
| Drafted CF D. Batchelor in the 2006 inaugural draft (Round 28, Pick 1, 55th overall Pick). |
| Drafted SP J. Carrasquillo in the 2006 inaugural draft (Round 29, Pick 1, 57th overall Pick). |
| Drafted CL E. Ortíz in the 2006 inaugural draft (Round 30, Pick 1, 59th overall Pick). |
| Drafted C C. Rivera in the 2006 inaugural draft (Round 31, Pick 1, 61st overall Pick). |
| Drafted 2B J. Howie in the 2006 inaugural draft (Round 32, Pick 1, 63rd overall Pick). |
| Drafted RF J. Rose in the 2006 inaugural draft (Round 33, Pick 1, 65th overall Pick). |
| Drafted SP J. Larralde in the 2006 inaugural draft (Round 34, Pick 1, 67th overall Pick). |
| Drafted MR J. Basham in the 2006 inaugural draft (Round 35, Pick 1, 69th overall Pick). |
| Drafted SS C. Speer in the 2006 inaugural draft (Round 36, Pick 1, 71st overall Pick). |
| Drafted SP B. Malkin in the 2006 inaugural draft (Round 37, Pick 1, 73rd overall Pick). |
| Drafted MR N. Cadigan in the 2006 inaugural draft (Round 38, Pick 1, 75th overall Pick). |
| Drafted MR G. Proctor in the 2006 inaugural draft (Round 39, Pick 1, 77th overall Pick). |
| Drafted MR F. Rengifo in the 2006 inaugural draft (Round 40, Pick 1, 79th overall Pick). |
| Drafted 2B J. García in the 2006 inaugural draft (Round 41, Pick 1, 81st overall Pick). |
| Drafted MR P. Olive in the 2006 inaugural draft (Round 42, Pick 1, 83rd overall Pick). |
| Drafted LF L. Butler in the 2006 inaugural draft (Round 43, Pick 1, 85th overall Pick). |
| Released SP R. Coker. |
| Released SP D. Kennahan. |
| Released SP Z. Newson. |
| Released SP C. O'Muleeny. |
| Released SP J. Pocklington. |
| Released MR L. Batista. |
| Released MR G. Scott. |
| Released MR C. Whipple. |
| Released CL E. Ortíz. |
| Released CL P. Parkman. |
| Released C A. Domínguez. |
| Released C K. Smith. |
| Released 1B T. Shrimpton. |
| Released 1B A. Chaney. |
| Released 2B E. Valadón. |
| Released 3B T. Tarter. |
| Released 3B B. Bagoim. |
| Released SS M. Knapp. |
| Released LF G. Foreman. |
| Released LF E. McShannachan. |
| Released CF M. Roach. |
| Released CF K. Bradley. |
| Released RF B. O'Danaher. |
| Placed SP J. Carrasquillo on the active roster. |
| Placed SP J. Larralde on the active roster. |
| Placed SP B. Malkin on the active roster. |
| Placed SP C. Young on the active roster. |
| Placed SP A. Salinas on the active roster. |
| Placed MR J. Basham on the active roster. |
| Placed MR N. Cadigan on the active roster. |
| Placed MR J. Castellar on the active roster. |
| Placed MR G. Proctor on the active roster. |
| Placed MR P. Olive on the active roster. |
| Placed MR M. Scott on the active roster. |
| Placed MR F. Rengifo on the active roster. |
| Placed C C. Rivera on the active roster. |
| Placed 1B Á. Cantorán on the active roster. |
| Placed 2B J. García on the active roster. |
| Placed 2B J. Howie on the active roster. |
| Placed SS C. Speer on the active roster. |
| Placed LF L. Butler on the active roster. |
| Placed CF D. Batchelor on the active roster. |
| Placed RF J. Rose on the active roster. |
| Released MR P. Olive. |
| Released SP J. Carrasquillo. |
| Released SP J. Larralde. |
| Released SP B. Malkin. |
| Released SP A. Salinas. |
| Released SP C. Young. |
| Released MR J. Basham. |
| Released MR N. Cadigan. |
| Released MR J. Castellar. |
| Released MR G. Proctor. |
| Released MR F. Rengifo. |
| Released MR M. Scott. |
| Released C C. Rivera. |
| Released 1B Á. Cantorán. |
| Released 2B J. Howie. |
| Released 2B J. García. |
| Released SS C. Speer. |
| Released LF L. Butler. |
| Released CF D. Batchelor. |
| Released RF J. Rose. |
| Placed SP S. Kazmir on the active roster. |
| Placed SP J. Santana on the active roster. |
| Placed SP C. Schilling on the active roster. |
| Placed SP J. Schmidt on the active roster. |
| Placed SP B. Webb on the active roster. |
| Placed CL B. Jenks on the active roster. |
| Placed CL J. Nathan on the active roster. |
| Placed CL C. Ray on the active roster. |
| Placed CL M. Rivera on the active roster. |
| Placed C R. Hernandez on the active roster. |
| Placed C J. Mauer on the active roster. |
| Placed 1B D. Ortiz on the active roster. |
| Placed 1B P. Konerko on the active roster. |
| Placed 2B A. Soriano on the active roster. |
| Placed 2B T. Iguchi on the active roster. |
| Placed 3B A. Rodriguez on the active roster. |
| Placed SS M. Young on the active roster. |
| Placed LF J. Bay on the active roster. |
| Placed LF C. Lee on the active roster. |
| Placed LF M. Holliday on the active roster. |
| Placed CF G. Sizemore on the active roster. |
| Placed RF J. Dye on the active roster. |
| Placed RF I. Suzuki on the active roster. |
