| Sunday, April 4th, 2010 |
| Drafted SP David Hirschfield in the 2010 inaugural draft (Round 1, Pick 1, 1st overall pick). |
| Drafted SS Robbie Beck in the 2010 inaugural draft (Round 2, Pick 1, 3rd overall pick). |
| Drafted LF Daryl McJannett in the 2010 inaugural draft (Round 3, Pick 1, 5th overall pick). |
| Drafted SP Francisco Navarro in the 2010 inaugural draft (Round 4, Pick 1, 7th overall pick). |
| Drafted 3B David Martínez in the 2010 inaugural draft (Round 5, Pick 1, 9th overall pick). |
| Drafted 1B Phil Ferguson in the 2010 inaugural draft (Round 6, Pick 1, 11th overall pick). |
| Drafted SP Bartolo González in the 2010 inaugural draft (Round 7, Pick 1, 13th overall pick). |
| Drafted C Ben MacKieson in the 2010 inaugural draft (Round 8, Pick 1, 15th overall pick). |
| Drafted RF Phil Johnson in the 2010 inaugural draft (Round 9, Pick 1, 17th overall pick). |
| Drafted MR Jeremy Pugh in the 2010 inaugural draft (Round 10, Pick 1, 19th overall pick). |
| Drafted SP Darby Thompson in the 2010 inaugural draft (Round 11, Pick 1, 21st overall pick). |
| Drafted 2B Donald Lyons in the 2010 inaugural draft (Round 12, Pick 1, 23rd overall pick). |
| Drafted SP Jay Walker in the 2010 inaugural draft (Round 13, Pick 1, 25th overall pick). |
| Drafted CL Pepe Icaza in the 2010 inaugural draft (Round 14, Pick 1, 27th overall pick). |
| Drafted CF Wally McGee in the 2010 inaugural draft (Round 15, Pick 1, 29th overall pick). |
| Drafted MR Andrew Nankervis in the 2010 inaugural draft (Round 16, Pick 1, 31st overall pick). |
| Drafted MR Veríssimo Salinas in the 2010 inaugural draft (Round 17, Pick 1, 33rd overall pick). |
| Drafted C Gary Guzmán in the 2010 inaugural draft (Round 18, Pick 1, 35th overall pick). |
| Drafted MR Tom Hancock in the 2010 inaugural draft (Round 19, Pick 1, 37th overall pick). |
| Drafted LF Manny Lazaro in the 2010 inaugural draft (Round 20, Pick 1, 39th overall pick). |
| Drafted SS Manfredino Buenaventura in the 2010 inaugural draft (Round 21, Pick 1, 41st overall pick). |
| Drafted 3B César Garza in the 2010 inaugural draft (Round 22, Pick 1, 43rd overall pick). |
| Drafted RF Paul Sparks in the 2010 inaugural draft (Round 23, Pick 1, 45th overall pick). |
| Released SP Bartolo González. |
| Released SP David Hirschfield. |
| Released SP Francisco Navarro. |
| Released SP Darby Thompson. |
| Released SP Jay Walker. |
| Released MR Tom Hancock. |
| Released MR Andrew Nankervis. |
| Released MR Jeremy Pugh. |
| Released MR Veríssimo Salinas. |
| Released CL Pepe Icaza. |
| Released C Ben MacKieson. |
| Released C Gary Guzmán. |
| Released 1B Phil Ferguson. |
| Released 2B Donald Lyons. |
| Released 3B César Garza. |
| Released 3B David Martínez. |
| Released SS Manfredino Buenaventura. |
| Released SS Robbie Beck. |
| Released LF Manny Lazaro. |
| Released LF Daryl McJannett. |
| Released CF Wally McGee. |
| Released RF Paul Sparks. |
| Released RF Phil Johnson. |
| Placed SP Clay Buchholz on the active roster. |
| Placed SP Chris Carpenter on the active roster. |
| Placed SP Clayton Kershaw on the active roster. |
| Placed SP Tim Lincecum on the active roster. |
| Placed SP Adam Wainwright on the active roster. |
| Placed MR Neftali Feliz on the active roster. |
| Placed CL Jonathan Broxton on the active roster. |
| Placed CL Mariano Rivera on the active roster. |
| Placed CL Brian Wilson on the active roster. |
| Placed C Jorge Posada on the active roster. |
| Placed C Joe Mauer on the active roster. |
| Placed 1B Kevin Youkilis on the active roster. |
| Placed 1B Justin Morneau on the active roster. |
| Placed 2B Dustin Pedroia on the active roster. |
| Placed 2B Martin Prado on the active roster. |
| Placed 2B Robinson Cano on the active roster. |
| Placed 3B Evan Longoria on the active roster. |
| Placed SS Hanley Ramirez on the active roster. |
| Placed LF Josh Hamilton on the active roster. |
| Placed LF Adam Dunn on the active roster. |
| Placed CF Torii Hunter on the active roster. |
| Placed CF Alex Rios on the active roster. |
| Placed CF Carlos Gonzalez on the active roster. |
