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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Cesar | C | Fayetteville Woodpeckers | 24 | 03/15/1996 | South Tucson | USA | Left | Right | 5' 9" | 190 lbs | - |
| Saldana, Abdiel | RP | Fayetteville Woodpeckers | 24 | 03/13/1996 | Panama | PAN | Right | Right | 5' 11" | 195 lbs | - |
| Sanabria, Carlos | RP | Fayetteville Woodpeckers | 23 | 01/24/1997 | La Victoria | VEN | Right | Right | 6' 3" | 165 lbs | - |
| Santana, Luis | 2B | Fayetteville Woodpeckers | 20 | 07/20/1999 | Baní | DOM | Right | Right | 5' 8" | 180 lbs | - |
| Schreiber, Scott | 1B | Fayetteville Woodpeckers | 24 | 10/13/1995 | Menasha | USA | Right | Right | 6' 3" | 230 lbs | - |
| Scott, Preston | RF | Carolina Mudcats | 26 | 11/15/1993 | Hanford | USA | Right | Right | 6' 2" | 210 lbs | - |
| Scott, Stephen | C | Salem Red Sox | 23 | 05/23/1997 | Cary | USA | Left | Right | 5' 11" | 200 lbs | - |
| Scrubb, Andre | RP | Free Agent | 25 | 01/13/1995 | Woodbridge | USA | Right | Right | 6' 4" | 265 lbs | - |
| Seise, Chris | 3B | Down East Wood Ducks | 21 | 01/06/1999 | Winter Garden | USA | Right | Right | 6' 2" | 175 lbs | - |
| Self, Derek | RP | Free Agent | 30 | 01/14/1990 | Cave City | USA | Right | Right | 6' 3" | 205 lbs | - |
| Senior, Eric | LF | Fredericksburg Nationals | 22 | 09/29/1997 | Toronto | CAN | Right | Right | 6' 2" | 170 lbs | - |
| Shaw, Josh | 2B | Fredericksburg Nationals | 23 | 11/30/1996 | Wayne | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sheller, Walker | RP | Wilmington Blue Rocks | 25 | 05/21/1995 | Abington Township | USA | Right | Right | 6' 3" | 195 lbs | - |
| Silva, Eddie | 3B | Carolina Mudcats | 24 | 04/12/1996 | Miramar | USA | Right | Right | 6' 0" | 220 lbs | - |
| Simmons, Cameron | LF | Winston-Salem Dash | 23 | 09/22/1996 | Royersford | USA | Right | Right | 6' 4" | 200 lbs | - |
| Siri, Dalbert | RP | Lynchburg Hillcats | 24 | 07/19/1995 | Moca | DOM | Right | Right | 6' 2" | 215 lbs | - |
| Skoglund, Eric | RP | Wilmington Blue Rocks | 27 | 10/26/1992 | Sarasota | USA | Left | Left | 6' 7" | 210 lbs | $568,175 |
| Skoug, Evan | C | Winston-Salem Dash | 24 | 10/21/1995 | Libertyville | USA | Left | Right | 5' 11" | 200 lbs | - |
| Smith, Austin | RP | Lynchburg Hillcats | 24 | 07/09/1996 | Boynton Beach | USA | Right | Right | 6' 4" | 250 lbs | - |
| Solis, Jairo | SP | Fayetteville Woodpeckers | 20 | 12/22/1999 | Puerto Cabello | VEN | Right | Right | 6' 2" | 160 lbs | - |
| Solomon, Peter | SP | Fayetteville Woodpeckers | 23 | 08/16/1996 | Ellicott City | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sosa, Lenyn | SS | Winston-Salem Dash | 20 | 01/25/2000 | Puerto Cabello | VEN | Right | Right | 6' 0" | 180 lbs | - |
| Sousa, Bennett | CL | Winston-Salem Dash | 25 | 04/06/1995 | North Palm Beach | USA | Left | Left | 6' 3" | 185 lbs | - |
| Sparks, Lamar | CF | Frederick Keys | 21 | 09/26/1998 | Katy | USA | Right | Right | 6' 2" | 170 lbs | - |
| Spooner, Mike | RF | Fredericksburg Nationals | 23 | 02/17/1997 | Boca Raton | USA | Left | Right | 6' 3" | 205 lbs | - |
| Strohschein, Kevin | RF | Fredericksburg Nationals | 22 | 07/25/1997 | McDonough | USA | Right | Right | 6' 1" | 215 lbs | - |
