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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Alejandro | 2B | Mississippi Braves | 23 | 10/05/1996 | Cabimas | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Sammons, Bryan | RP | Pensacola Blue Wahoos | 25 | 04/27/1995 | Wilmington | USA | Left | Left | 6' 4" | 235 lbs | - |
| Sampen, Caleb | SP | Montgomery Biscuits | 23 | 07/23/1996 | Brownsburg | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sanchez, Jesus | CF | Jacksonville Jumbo Shrimp | 22 | 10/07/1997 | Higüey | DOM | Left | Right | 6' 3" | 230 lbs | - |
| Sanchez, Miguel | RP | Biloxi Shuckers | 26 | 12/31/1993 | Bonao | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Sanders, Phoenix | RP | Montgomery Biscuits | 25 | 06/05/1995 | Augsburg | GER | Right | Right | 5' 10" | 185 lbs | - |
| Sanger, Brendon | 2B | Rocket City Trash Pandas | 26 | 09/11/1993 | York | USA | Left | Right | 6' 0" | 195 lbs | - |
| Santana Jr., Andres | CF | Chattanooga Lookouts | 21 | 11/05/1998 | Miami | USA | Right | Right | 6' 1" | 180 lbs | - |
| Santillan, Tony | SP | Chattanooga Lookouts | 23 | 04/15/1997 | Arlington | USA | Right | Right | 6' 3" | 240 lbs | - |
| Serena, Jordan | C | Chattanooga Lookouts | 27 | 08/04/1992 | Parker | USA | Right | Right | 6' 1" | 220 lbs | - |
| Shafer, Justin | RP | Biloxi Shuckers | 27 | 09/18/1992 | Lake Wales | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shaffer, Brian | SP | Montgomery Biscuits | 23 | 08/12/1996 | Baltimore | USA | Right | Right | 6' 5" | 200 lbs | - |
| Sheets, Gavin | 1B | Birmingham Barons | 24 | 04/23/1996 | Lutherville-Timonium | USA | Left | Left | 6' 4" | 230 lbs | - |
| Shepherd, Chandler | RP | Mississippi Braves | 27 | 08/25/1992 | Louisa | USA | Right | Right | 6' 3" | 185 lbs | - |
| Snyder, Michael | 1B | Pensacola Blue Wahoos | 30 | 06/17/1990 | Centreville | USA | Right | Right | 6' 4" | 240 lbs | - |
| Sodders, Austin | SP | Jacksonville Jumbo Shrimp | 25 | 04/29/1995 | Riverside | USA | Left | Left | 6' 4" | 205 lbs | - |
| Soriano, Franklyn | RP | Chattanooga Lookouts | 24 | 07/21/1995 | San Gregorio de Nigua | DOM | Left | Left | 6' 5" | 195 lbs | - |
| Spanberger, Chad | 1B | Biloxi Shuckers | 24 | 11/01/1995 | Granite City | USA | Left | Right | 6' 3" | 235 lbs | - |
| Sparks, Taylor | 3B | Jacksonville Jumbo Shrimp | 27 | 04/03/1993 | La Palma | USA | Right | Right | 6' 4" | 200 lbs | - |
| Spillane, Bren | 1B | Chattanooga Lookouts | 23 | 09/21/1996 | Wheeling | USA | Right | Right | 6' 4" | 225 lbs | - |
| Steele, Justin | SP | Tennessee Smokies | 25 | 07/11/1995 | Lucedale | USA | Left | Left | 6' 2" | 205 lbs | - |
| Stefanic, Michael | 1B | Rocket City Trash Pandas | 24 | 02/24/1996 | Teutopolis | USA | Right | Right | 5' 10" | 180 lbs | - |
| Stevenson, Cal | RF | Montgomery Biscuits | 23 | 09/12/1996 | Fremont | USA | Left | Left | 5' 10" | 175 lbs | - |
| Stewart, Chris | C | Rocket City Trash Pandas | 38 | 02/19/1982 | Fontana | USA | Right | Right | 6' 4" | 210 lbs | - |
| Sullivan, Brett | C | Montgomery Biscuits | 26 | 02/22/1994 | Stockton | USA | Left | Right | 6' 1" | 195 lbs | - |
| Swarmer, Matt | RP | Tennessee Smokies | 26 | 09/25/1993 | Mohnton | USA | Right | Right | 6' 5" | 200 lbs | - |
