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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saalfrank, Andrew | RP | Hillsboro Hops | 22 | 08/18/1997 | Monroeville | USA | Left | Left | 6' 3" | 205 lbs | - |
| Salas, Ken | RP | Salem-Keizer Volcanoes | 18 | 07/30/2001 | Hato Mayor | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Salvatore, Mike | 2B | Everett AquaSox | 23 | 12/27/1996 | Ewing | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sanders, Cam | SP | Eugene Emeralds | 23 | 12/09/1996 | Thibodaux | USA | Right | Right | 6' 2" | 175 lbs | - |
| Santa Cruz, JJ | RP | Free Agent | 24 | 01/15/1996 | Tucson | USA | Left | Left | 6' 7" | 220 lbs | - |
| Santana, Yeison | RP | Eugene Emeralds | 23 | 10/25/1996 | Villa Jaragua | DOM | Right | Right | 6' 0" | 180 lbs | - |
| Satterwhite, Cody | RP | Boise Hawks | 33 | 01/27/1987 | Jackson | USA | Right | Right | 6' 4" | 235 lbs | - |
| Scheffler, Matt | C | Salem-Keizer Volcanoes | 22 | 02/06/1998 | Kirkland | USA | Right | Right | 6' 2" | 190 lbs | - |
| Schlereth, Daniel | RP | Boise Hawks | 34 | 05/09/1986 | Anchorage | USA | Left | Left | 6' 0" | 210 lbs | - |
| Schneider, Davis | 3B | Vancouver Canadians | 21 | 01/26/1999 | Berlin | USA | Right | Right | 5' 10" | 190 lbs | - |
| Schuster, Patrick | RP | Tri-City Dust Devils | 29 | 10/30/1990 | New Port Richey | USA | Right | Left | 6' 2" | 190 lbs | - |
| Scott, Braden | CL | Eugene Emeralds | 22 | 02/06/1998 | Jasonville | USA | Left | Left | 6' 3" | 200 lbs | - |
| Scroggins, Cody | RP | Hillsboro Hops | 23 | 08/17/1996 | Bentonville | USA | Right | Right | 6' 0" | 195 lbs | - |
| Shannon, Zack | RF | Hillsboro Hops | 24 | 06/22/1996 | Cincinnati | USA | Right | Right | 6' 3" | 230 lbs | - |
| Sierra, Diomede | SP | Hillsboro Hops | 18 | 09/11/2001 | Santo Domingo | DOM | Left | Left | 6' 2" | 170 lbs | - |
| Sierra, Jonathan | LF | Eugene Emeralds | 21 | 10/17/1998 | Santo Domingo | DOM | Left | Left | 6' 3" | 190 lbs | - |
| Silva, Luis | 3B | Free Agent | 25 | 06/30/1995 | Valencia | VEN | Right | Right | 5' 11" | 170 lbs | - |
| Slaten, Justin | RP | Spokane Indians | 22 | 09/15/1997 | Longview | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sloniger, Ryan | C | Vancouver Canadians | 23 | 03/20/1997 | Punxsutawney | USA | Left | Right | 5' 11" | 200 lbs | - |
| Smith, Armani | LF | Salem-Keizer Volcanoes | 21 | 07/19/1998 | Concord | USA | Right | Right | 6' 4" | 215 lbs | - |
| Smith, Chad | LF | Spokane Indians | 22 | 09/30/1997 | Snellville | USA | Left | Left | 6' 2" | 200 lbs | - |
| Smith, Josh | SP | Spokane Indians | 23 | 02/05/1997 | Saline | USA | Left | Left | 6' 5" | 205 lbs | - |
| Snyder, Nick | RP | Hillsboro Hops | 22 | 11/19/1997 | Marlton | USA | Left | Left | 6' 7" | 220 lbs | - |
| Solomon, Lee | 1B | Tri-City Dust Devils | 23 | 08/06/1996 | Columbus | USA | Right | Right | 5' 10" | 200 lbs | - |
| Soto, Isael | RF | Eugene Emeralds | 23 | 11/02/1996 | Baní | DOM | Left | Left | 6' 0" | 190 lbs | - |
| Soto, Jonathan | 1B | Eugene Emeralds | 22 | 07/09/1998 | Unknown | VEN | Left | Right | 5' 9" | 145 lbs | - |
| Stambaugh, Dalton | SP | Salem-Keizer Volcanoes | 23 | 02/11/1997 | Morehead | USA | Right | Left | 6' 0" | 195 lbs | - |
| Steinmetz, Hunter | CF | Vancouver Canadians | 23 | 12/13/1996 | Springfield | USA | Left | Left | 5' 9" | 175 lbs | - |
| Stock, Dylan | RP | Hillsboro Hops | 23 | 07/21/1996 | Bellmore | USA | Right | Right | 6' 4" | 195 lbs | - |
| Stronach, Jack | 3B | Tri-City Dust Devils | 22 | 08/02/1997 | La Mesa | USA | Left | Right | 6' 3" | 195 lbs | - |
| Strumpf, Chase | 2B | Eugene Emeralds | 22 | 03/08/1998 | Ladera Heights | USA | Right | Right | 6' 1" | 195 lbs | - |
