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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saez, Jhoander | CF | Kingsport Mets | 22 | 03/24/1998 | Porlamar | VEN | Switch | Right | 6' 0" | 165 lbs | - |
| Salva, Kidany | C | Elizabethton Twins | 21 | 08/24/1998 | Unknown | USA | Left | Right | 5' 11" | 185 lbs | - |
| Sanchez, Ricardo | C | Burlington Royals | 25 | 05/04/1995 | Dorado | PUR | Left | Right | 5' 9" | 185 lbs | - |
| Santiago, Benny | C | Elizabethton Twins | 25 | 03/31/1995 | Pembroke Pines | USA | Left | Right | 6' 0" | 195 lbs | - |
| Saunders, Garrett | SS | Danville Braves | 23 | 12/03/1996 | Bonaparte | USA | Right | Right | 6' 0" | 190 lbs | - |
| Schaller, Jonah | CL | Bristol Pirates | 20 | 05/01/2000 | Düdingen | SUI | Right | Right | 5' 11" | 185 lbs | - |
| Schmid, Colin | SP | Johnson City Cardinals | 22 | 08/13/1997 | New Bern | USA | Left | Left | 6' 1" | 195 lbs | - |
| Schmidt, Kyle | C | Elizabethton Twins | 23 | 07/13/1997 | Smithville | USA | Right | Right | 6' 0" | 205 lbs | - |
| Scott, Jordan | SP | Johnson City Cardinals | 25 | 04/03/1995 | Atlanta | USA | Right | Right | 6' 3" | 190 lbs | - |
| Scott, Levi | 1B | Elizabethton Twins | 27 | 08/04/1992 | Burleson | USA | Right | Right | 6' 4" | 215 lbs | - |
| Sellers, Matt | SP | Danville Braves | 23 | 01/29/1997 | Vero Beach | USA | Right | Right | 6' 1" | 185 lbs | - |
| Seltzer, Brandon | RF | Greeneville Reds | 22 | 05/19/1998 | New York | USA | Right | Right | 6' 2" | 200 lbs | - |
| Severino, Jesus | CF | Pulaski Yankees | 20 | 06/07/2000 | Nirgua | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Shepherd, Cam | 2B | Danville Braves | 22 | 09/28/1997 | Duluth | USA | Right | Right | 6' 1" | 180 lbs | - |
| Shinn, Ryan | RF | Kingsport Mets | 23 | 12/09/1996 | Springfield | USA | Right | Left | 6' 2" | 215 lbs | - |
| Shockley, Dylan | C | Bristol Pirates | 23 | 04/10/1997 | Harrison | USA | Right | Right | 5' 11" | 195 lbs | - |
| Silva, Nixon | RP | Kingsport Mets | 20 | 08/20/1999 | Ciudad Bolívar | VEN | Left | Left | 5' 10" | 165 lbs | - |
| Smiddy, Shay | RP | Princeton Rays | 22 | 12/19/1997 | Defiance | USA | Right | Right | 6' 5" | 215 lbs | - |
| Smith, Brady | C | Bristol Pirates | 21 | 11/18/1998 | Niceville | USA | Right | Right | 6' 0" | 195 lbs | - |
| Smith, Isaiah | LF | Burlington Royals | 21 | 06/19/1999 | Battle Ground | USA | Right | Right | 6' 3" | 190 lbs | - |
| Smith, Max | LF | Elizabethton Twins | 23 | 03/10/1997 | Tucson | USA | Left | Right | 6' 1" | 200 lbs | - |
| Smith, Sincere | SS | Pulaski Yankees | 20 | 03/13/2000 | Elizabethtown | USA | Right | Right | 5' 11" | 170 lbs | - |
| Solarte, Jhon | LF | Bluefield Blue Jays | 19 | 12/09/2000 | Unknown | VEN | Switch | Right | 6' 0" | 165 lbs | - |
| Spacke, Dylan | RP | Kingsport Mets | 22 | 03/11/1998 | San Diego | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Steer, Spencer | SS | Elizabethton Twins | 22 | 12/07/1997 | Long Beach | USA | Right | Right | 5' 11" | 185 lbs | - |
| Strzelecki, Peter | SP | Johnson City Cardinals | 25 | 10/24/1994 | New York | USA | Right | Right | 6' 2" | 195 lbs | - |
| Suarez, Ronald | CL | Johnson City Cardinals | 20 | 03/05/2000 | Santo Domingo | DOM | Right | Right | 6' 4" | 215 lbs | - |
| Sung, Wen-Hua | RP | Free Agent | 23 | 09/02/1996 | Taitung | TPE | Right | Right | 6' 1" | 200 lbs | - |
| Sutera, Tom | RP | Kingsport Mets | 23 | 05/29/1997 | Waterford | USA | Right | Right | 6' 5" | 190 lbs | - |
