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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sadzeck, Connor | RP | Charlotte Knights | 28 | 10/01/1991 | Crystal Lake | USA | Right | Right | 6' 7" | 240 lbs | $563,500 |
| Sanchez, Cristopher | SP | Lehigh Valley IronPigs | 23 | 12/12/1996 | La Romana | DOM | Left | Left | 6' 5" | 165 lbs | - |
| Sanchez, Filyer | RP | Toledo Mud Hens | 23 | 02/08/1997 | San Felipe | VEN | Left | Left | 6' 1" | 175 lbs | - |
| Sanchez, Yolbert | SS | Charlotte Knights | 23 | 03/03/1997 | Havana | CUB | Right | Right | 5' 11" | 175 lbs | - |
| Sanmartin, Reiver | SP | Louisville Bats | 24 | 04/15/1996 | Cartagena | COL | Left | Left | 6' 2" | 165 lbs | - |
| Santana, Edgar | CL | Indianapolis Indians | 28 | 10/16/1991 | Puerto Plata | DOM | Right | Right | 6' 2" | 190 lbs | $581,500 |
| Santiago, Hector | RP | Toledo Mud Hens | 32 | 12/16/1987 | Newark | USA | Right | Left | 6' 0" | 215 lbs | - |
| Sawyer, Wynston | C | Scranton WB RailRiders | 28 | 11/14/1991 | San Diego | USA | Right | Right | 6' 3" | 215 lbs | - |
| Schebler, Scott | LF | Louisville Bats | 29 | 10/06/1990 | Cedar Rapids | USA | Left | Right | 6' 0" | 230 lbs | $625,000 |
| Schimpf, Ryan | 3B | Lehigh Valley IronPigs | 32 | 04/11/1988 | Covington | USA | Left | Right | 5' 9" | 180 lbs | $950,000 |
| Schroeder, Casey | C | Rochester Red Wings | 27 | 07/12/1993 | Ottawa | USA | Switch | Right | 6' 2" | 225 lbs | - |
| Schryver, Hunter | RP | Charlotte Knights | 25 | 04/03/1995 | Mechanicsburg | USA | Left | Left | 6' 1" | 200 lbs | - |
| Schwindel, Frank | 1B | Toledo Mud Hens | 28 | 06/29/1992 | Livingston | USA | Right | Right | 6' 1" | 215 lbs | - |
| Scruggs, Xavier | 1B | Rochester Red Wings | 32 | 09/23/1987 | Poway | USA | Right | Right | 6' 0" | 215 lbs | $840,000 |
| Semple, Shawn | SP | Scranton WB RailRiders | 24 | 10/09/1995 | Swedesboro | USA | Right | Right | 6' 1" | 220 lbs | - |
| Sever, Joe | SS | Columbus Clippers | 29 | 08/12/1990 | San Jose | USA | Right | Right | 6' 0" | 205 lbs | - |
| Severino, Pedro | C | Norfolk Tides | 26 | 07/20/1993 | Bonao | DOM | Right | Right | 6' 1" | 220 lbs | $563,500 |
| Sewald, Paul | CL | Syracuse Mets | 30 | 05/26/1990 | Las Vegas | USA | Right | Right | 6' 3" | 205 lbs | - |
| Shewmake, Braden | 2B | Gwinnett Stripers | 22 | 11/19/1997 | Wylie | USA | Left | Right | 6' 4" | 195 lbs | $563,500 |
| Sims, Lucas | SP | Louisville Bats | 26 | 05/10/1994 | Lawrenceville | USA | Right | Right | 6' 2" | 225 lbs | $563,500 |
| Skole, Matt | 1B | Charlotte Knights | 30 | 07/30/1989 | Woodstock | USA | Left | Right | 6' 4" | 220 lbs | - |
| Skubal, Tarik | SP | Toledo Mud Hens | 23 | 11/20/1996 | Kingman | USA | Left | Left | 6' 3" | 215 lbs | - |
| Slegers, Aaron | RP | Durham Bulls | 27 | 09/04/1992 | Scottsdale | USA | Right | Right | 6' 10" | 245 lbs | - |
| Smeltzer, Devin | RP | Rochester Red Wings | 24 | 09/07/1995 | Voorheesville | USA | Right | Left | 6' 3" | 195 lbs | - |
| Smith, Dominic | 1B | Syracuse Mets | 25 | 06/15/1995 | Los Angeles | USA | Left | Left | 6' 0" | 235 lbs | $563,500 |
| Smith, Kevin | SP | Syracuse Mets | 23 | 05/13/1997 | Dunwoody | USA | Right | Left | 6' 5" | 200 lbs | $563,500 |
| Solarte, Yangervis | 1B | Gwinnett Stripers | 33 | 07/03/1987 | Valencia | VEN | Switch | Right | 5' 11" | 200 lbs | $563,500 |
| Soto, Gregory | SP | Toledo Mud Hens | 25 | 02/11/1995 | Bajos de Haina | DOM | Left | Left | 6' 1" | 240 lbs | - |
| Stallings, Mitch | RP | Gwinnett Stripers | 25 | 06/30/1995 | Atlanta | USA | Left | Left | 6' 2" | 180 lbs | - |
| Stephens, Jordan | RP | Columbus Clippers | 27 | 09/12/1992 | Alvin | USA | Right | Right | 6' 1" | 190 lbs | - |
| Stewart, Christin | LF | Toledo Mud Hens | 26 | 12/10/1993 | Lawrenceville | USA | Left | Right | 6' 0" | 205 lbs | $563,500 |
| Stewart, Kohl | SP | Norfolk Tides | 25 | 10/07/1994 | Tomball | USA | Right | Right | 6' 3" | 195 lbs | $800,000 |
| Stock, Robert | CL | Lehigh Valley IronPigs | 30 | 11/21/1989 | Bellevue | USA | Left | Right | 6' 1" | 215 lbs | $563,500 |
| Strickland, Hunter | RP | Scranton WB RailRiders | 31 | 09/24/1988 | Thomaston | USA | Right | Right | 6' 3" | 225 lbs | $1,120,000 |
| Stumpf, Daniel | RP | Columbus Clippers | 29 | 01/04/1991 | Humble | USA | Left | Left | 6' 2" | 210 lbs | $563,500 |
| Suarez, Ranger | SP | Lehigh Valley IronPigs | 24 | 08/26/1995 | Carora | VEN | Left | Left | 6' 1" | 185 lbs | $563,500 |
| Susac, Andrew | C | Indianapolis Indians | 30 | 03/22/1990 | Roseville | USA | Right | Right | 6' 1" | 215 lbs | - |
| Szapucki, Thomas | SP | Syracuse Mets | 24 | 06/12/1996 | Palm Beach Gardens | USA | Right | Left | 6' 2" | 185 lbs | - |
| Szczur, Matt | LF | Lehigh Valley IronPigs | 30 | 07/20/1989 | Cape May | USA | Right | Right | 6' 0" | 200 lbs | - |
