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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Eaton, Adam | RF | Washington Nationals | 31 | 12/06/1988 | Springfield | USA | Left | Left | 5' 9" | 180 lbs | $9,500,000 |
| Echenique, Luis | CF | Kansas City Royals | 17 | 11/25/2002 | Cúa | VEN | Left | Left | 5' 11" | 175 lbs | - |
| Edman, Tommy | 2B | St. Louis Cardinals | 25 | 05/09/1995 | San Diego | USA | Switch | Right | 5' 10" | 180 lbs | $563,500 |
| Edwards Jr., Carl | RP | Seattle Mariners | 28 | 09/03/1991 | Newberry | USA | Right | Right | 6' 3" | 170 lbs | $950,000 |
| Eflin, Zach | SP | Philadelphia Phillies | 26 | 04/08/1994 | Chuluota | USA | Right | Right | 6' 6" | 215 lbs | $2,625,000 |
| Eickhoff, Jerad | SP | Baltimore Orioles | 30 | 07/02/1990 | Evansville | USA | Right | Right | 6' 4" | 245 lbs | $563,500 |
| Elbis, Joe | RP | Arizona Diamondbacks | 17 | 09/24/2002 | Caracas | VEN | Right | Right | 6' 1" | 150 lbs | - |
| Elias, Roenis | RP | Washington Nationals | 31 | 08/01/1988 | Guantanamo | CUB | Left | Left | 6' 1" | 205 lbs | $1,975,000 |
| Encarnacion, Edwin | 1B | Chicago White Sox | 37 | 01/07/1983 | La Romana | DOM | Right | Right | 6' 1" | 230 lbs | $11,000,000 |
| Engel, Adam | CF | Chicago White Sox | 28 | 12/09/1991 | Loveland | USA | Right | Right | 6' 2" | 210 lbs | $571,000 |
| Eovaldi, Nathan | SP | Boston Red Sox | 30 | 02/13/1990 | Alvin | USA | Right | Right | 6' 2" | 225 lbs | $17,000,000 |
| Erlin, Robbie | RP | Pittsburgh Pirates | 29 | 10/08/1990 | Santa Cruz | USA | Right | Left | 6' 0" | 190 lbs | $563,500 |
| Escalona, Eybert | C | Pittsburgh Pirates | 17 | 10/27/2002 | Barquisimeto | VEN | Right | Right | 6' 0" | 180 lbs | - |
| Escobar, Eduardo | 3B | Arizona Diamondbacks | 31 | 01/05/1989 | Villa de Cura | VEN | Switch | Right | 5' 10" | 185 lbs | $7,000,000 |
| Espana, Juan | RP | New York Yankees | 18 | 02/19/2002 | Sincelejo | COL | Right | Right | 5' 9" | 145 lbs | - |
| Espino, Ruben | SP | Houston Astros | 17 | 07/05/2003 | Maracaibo | VEN | Right | Right | 6' 4" | 180 lbs | - |
| Espinoza, Iverson | SS | Cincinnati Reds | 17 | 01/06/2003 | Maracay | VEN | Right | Right | 5' 10" | 155 lbs | - |
| Espinoza, Lizandro | SS | St. Louis Cardinals | 17 | 11/20/2002 | Higuerote | VEN | Right | Right | 5' 7" | 155 lbs | - |
| Esquivel, Francis | SP | Philadelphia Phillies | 17 | 05/11/2003 | Puerto la Cruz | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Estaba, Gabriel | RP | New York Mets | 17 | 01/23/2003 | Puerto la Cruz | VEN | Right | Right | 6' 5" | 155 lbs | - |
| Estanista, Jaydenn | SP | Philadelphia Phillies | 18 | 10/03/2001 | Willemstad | CUR | Right | Right | 6' 3" | 180 lbs | - |
| Estevez, Carlos | RP | Colorado Rockies | 27 | 12/28/1992 | Santo Domingo | DOM | Right | Right | 6' 6" | 275 lbs | $1,080,000 |
| Estrada, Manny | SP | Seattle Mariners | 17 | 07/11/2003 | Mariara | VEN | Left | Right | 6' 6" | 195 lbs | - |
